Heterogeneity in pulmonary emphysema: Analysis of CT attenuation using Gaussian mixture model.

ABSTRACT:

Purpose

To utilize Gaussian mixture model (GMM) for the quantification of chronic obstructive pulmonary disease (COPD) and to evaluate the combined use of multiple types of quantification.

Materials and methods

Eighty-seven patients (67 men, 20 women; age, 67.4 ± 11.0 years) who had undergone computed tomography (CT) and pulmonary function test (PFT) were included. The heterogeneity of CT attenuation in emphysema (HC) was obtained by analyzing a distribution of CT attenuation with GMM. The percentages of low-attenuation volume in the lungs (LAV), wall area of bronchi (WA), and the cross-sectional area of small pulmonary vessels (CSA) were also calculated. The relationships between COPD quantifications and the PFT results were evaluated by Pearson's correlation coefficients a

SUBMITTER: Nishio M 

PROVIDER: S-EPMC5812649 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature