Correcting Nonpathological Variation in Longitudinal Parametric Response Maps of CT Scans in COPD Subjects: SPIROMICS.

ABSTRACT: Small airways disease (SAD) is one of the leading causes of airflow limitations in patients diagnosed with chronic obstructive pulmonary disease (COPD). Parametric response mapping (PRM) of computed tomography (CT) scans allows for the quantification of this previously invisible COPD component. Although PRM is being investigated as a diagnostic tool for COPD, variability in the longitudinal measurements of SAD by PRM has been reported. Here, we show a method for correcting longitudinal PRM data because of non-pathological variations in serial CT scans. In this study, serial whole-lung high-resolution CT scans over a 30-day interval were obtained from 90 subjects with and without COPD accrued as part of SPIROMICS. It was assumed in all subjects that the COPD did not progress between examina

SUBMITTER: Fernandez-Baldera A 

PROVIDER: S-EPMC5812694 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature