Mortality Risk Prediction in Scleroderma-Related Interstitial Lung Disease: The SADL Model.

ABSTRACT:

Background

Interstitial lung disease (ILD) is an important cause of morbidity and mortality in patients with scleroderma (Scl). Risk prediction and prognostication in patients with Scl-ILD are challenging because of heterogeneity in the disease course.

Methods

We aimed to develop a clinical mortality risk prediction model for Scl-ILD. Patients with Scl-ILD were identified from two ongoing longitudinal cohorts: 135 patients at the University of California, San Francisco (derivation cohort) and 90 patients at the Mayo Clinic (validation cohort). Using these two separate cohorts, a mortality risk prediction model was developed and validated by testing every potential candidate Cox model, each including three or four variables of a possible 19 clinical predictors, for time to de

SUBMITTER: Morisset J 

PROVIDER: S-EPMC5812750 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature