Clinical and Genetic Associations of Objectively Identified Interstitial Changes in Smokers.

ABSTRACT:

Background

Smoking-related lung injury may manifest on CT scans as both emphysema and interstitial changes. We have developed an automated method to quantify interstitial changes and hypothesized that this measurement would be associated with lung function, quality of life, mortality, and a mucin 5B (MUC5B) polymorphism.

Methods

Using CT scans from the Genetic Epidemiology of COPD Study, we objectively labeled lung parenchyma as a tissue subtype. We calculated the percentage of the lung occupied by interstitial subtypes.

Results

A total of 8,345 participants had clinical and CT scanning data available. A 5% absolute increase in interstitial changes was associated with an absolute decrease in FVC % predicted of 2.47% (P < .001) and a 1.36-point higher St. George's Resp

SUBMITTER: Ash SY 

PROVIDER: S-EPMC5812756 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature