Procalcitonin as an Early Marker of the Need for Invasive Respiratory or Vasopressor Support in Adults With Community-Acquired Pneumonia.

ABSTRACT:

Background

Predicting the need for intensive care among adults with community-acquired pneumonia (CAP) remains challenging.

Methods

Using a multicenter prospective cohort study of adults hospitalized with CAP, we evaluated the association of serum procalcitonin (PCT) concentration at hospital presentation with the need for invasive respiratory or vasopressor support (IRVS), or both, within 72 h. Logistic regression was used to model this association, with results reported as the estimated risk of IRVS for a given PCT concentration. We also assessed whether the addition of PCT changed the performance of established pneumonia severity scores, including the pneumonia severity index and the American Thoracic Society minor criteria, for prediction of IRVS.

Results

Of 1,770

SUBMITTER: Self WH 

PROVIDER: S-EPMC5812770 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature