Earlier post-operative hypocortisolemia may predict durable remission from Cushing's disease.

ABSTRACT:

Context

Achievement of hypocortisolemia following transsphenoidal surgery (TSS) for Cushing's disease (CD) is associated with successful adenoma resection. However, up to one-third of these patients recur.

Objective

We assessed whether delay in reaching post-operative cortisol nadir may delineate patients at risk of recurrence for CD following TSS.

Methods

A retrospective review of 257 patients who received 291 TSS procedures for CD at NIH, between 2003 and 2016. Early biochemical remission (serum cortisol nadir <5 μg/dL) was confirmed with endocrinological and clinical follow-up. Recurrence was detected by laboratory testing, clinical stigmata or medication dependence during a median follow-up of 11 months.

Results

Of the 268 unique admissions, remission was r

SUBMITTER: Ironside N 

PROVIDER: S-EPMC5812811 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature