Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion.

ABSTRACT: Ionizing radiation (IR) is commonly used to treat central nervous system (CNS) cancers and metastases. While IR promotes remission, frequent side effects including impaired cognition and white matter loss occur following treatment. Fractionation is used to minimize these CNS late side effects, as it reduces IR effects in differentiated normal tissue, but not rapidly proliferating normal or tumor tissue. However, side effects occur even with the use of fractionated paradigms. Oligodendrocyte progenitor cells (OPCs) are a proliferative population within the CNS affected by radiation. We hypothesized that fractionated radiation would lead to OPC loss, which could contribute to the delayed white matter loss seen after radiation exposure. We found that fractionated IR induced a greater early lo

SUBMITTER: Begolly S 

PROVIDER: S-EPMC5812816 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature