Tissue Engineered Bone Differentiated From Human Adipose Derived Stem Cells Inhibit Posterolateral Fusion in an Athymic Rat Model.

ABSTRACT:

Study design

Biological augmentation spinal arthrodesis trial in athymic rats.

Objective

To assess the efficacy of tissue-engineered bone to promote L4-L5 intertransverse process fusion in an athymic rat model.

Summary of background data

Each year in the United States, over 400,000 spinal fusion surgeries are performed requiring bone graft. The current gold standard for posterolateral lumbar fusion is autogenous iliac crest bone graft (ICBG), but the harvesting of ICBG is associated with increased operative time and significant complications. This being the case, an alternative cost-effective bone graft source is needed.

Methods

Bovine bone cores were sterilized and decellularized for scaffold production. Human adipose derived mesenchymal stem cells (ADSC) were

SUBMITTER: Saifi C 

PROVIDER: S-EPMC5812848 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature