N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism.

ABSTRACT: Obesity is a major health problem, and although caloric restriction and exercise are successful strategies to lose adipose tissue in obese individuals, a simultaneous decrease in skeletal muscle mass, negatively effects metabolism and muscle function. To deeper understand molecular events occurring in muscle during weight-loss, we measured the expressional change in human skeletal muscle following a combination of severe caloric restriction and exercise over 4 days in 15 Swedish men. Key metabolic genes were regulated after the intervention, indicating a shift from carbohydrate to fat metabolism. Nicotinamide N-methyltransferase (NNMT) was the most consistently upregulated gene following the energy-deficit exercise. Circulating levels of N1-methylnicotinamide (MNA), the product of NNMT act

SUBMITTER: Strom K 

PROVIDER: S-EPMC5813101 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature