Colorectal Cancer-Associated Genes Are Associated with Tooth Agenesis and May Have a Role in Tooth Development.

ABSTRACT: Previously reported co-occurrence of colorectal cancer (CRC) and tooth agenesis (TA) and the overlap in disease-associated gene variants suggest involvement of similar molecular pathways. Here, we took an unbiased approach and tested genome-wide significant CRC-associated variants for association with isolated TA. Thirty single nucleotide variants (SNVs) in CRC-predisposing genes/loci were genotyped in a discovery dataset composed of 440 individuals with and without isolated TA. Genome-wide significant associations were found between TA and ATF1 rs11169552 (P = 4.36 × 10^-10) and DUSP10 rs6687758 (P = 1.25 × 10^-9), and positive association found with CASC8 rs10505477 (P = 8.2 × 10^-5). Additional CRC marker haplotypes were also significantly associated with T

SUBMITTER: Williams MA 

PROVIDER: S-EPMC5813178 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature