Development and validation of prognostic survival models in newly diagnosed Parkinson's disease.

ABSTRACT:

Objective

The objective of this study was to develop valid prognostic models to predict mortality, dependency, and "death or dependency" for use in newly diagnosed Parkinson's disease (PD).

Methods

The models were developed in the Parkinsonism Incidence in North-East Scotland study (UK, 198 patients) and validated in the ParkWest study (Norway, 192 patients), cohorts that attempted to identify and follow-up all new PD cases in the study area. Dependency was defined using the Schwab & England scale. We selected variables measured at time of diagnosis to include in the models. Internal validation and external validation were performed by calculating C-statistics (discrimination) and plotting observed versus predicted risk in quantiles of predicted risk (calibration).

Result

SUBMITTER: Macleod AD 

PROVIDER: S-EPMC5813201 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature