Parent-of-origin-environment interactions in case-parent triads with or without independent controls.

ABSTRACT: With case-parent triad data, one can frequently deduce parent of origin of the child's alleles. This allows a parent-of-origin (PoO) effect to be estimated as the ratio of relative risks associated with the alleles inherited from the mother and the father, respectively. A possible cause of PoO effects is DNA methylation, leading to genomic imprinting. Because environmental exposures may influence methylation patterns, gene-environment interaction studies should be extended to allow for interactions between PoO effects and environmental exposures (i.e., PoOxE). One should thus search for loci where the environmental exposure modifies the PoO effect. We have developed an extensive framework to analyze PoOxE effects in genome-wide association studies (GWAS), based on complete or incomplete ca

SUBMITTER: Gjerdevik M 

PROVIDER: S-EPMC5813215 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature