Whole bone testing in small animals: systematic characterization of the mechanical properties of different rodent bones available for rat fracture models.

ABSTRACT:

Objectives

Rat fracture models are extensively used to characterize normal and pathological bone healing. Despite, systematic research on inter- and intra-individual differences of common rat bones examined is surprisingly not available. Thus, we studied the biomechanical behaviour and radiological characteristics of the humerus, the tibia and the femur of the male Wistar rat-all of which are potentially available in the experimental situation-to identify useful or detrimental biomechanical properties of each bone and to facilitate sample size calculations.

Methods

40 paired femura, tibiae and humeri of male Wistar rats (10-38 weeks, weight between 240 and 720 g) were analysed by DXA, pQCT scan and three-point-bending. Bearing and loading bars of the biomechanical setup were

SUBMITTER: Prodinger PM 

PROVIDER: S-EPMC5813325 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature