Using OWL reasoning to support the generation of novel gene sets for enrichment analysis.

ABSTRACT: BACKGROUND:The Gene Ontology (GO) consists of over 40,000 terms for biological processes, cell components and gene product activities linked into a graph structure by over 90,000 relationships. It has been used to annotate the functions and cellular locations of several million gene products. The graph structure is used by a variety of tools to group annotated genes into sets whose products share function or location. These gene sets are widely used to interpret the results of genomics experiments by assessing which sets are significantly over- or under-represented in results lists. F Hoffmann-La Roche Ltd. has developed a bespoke, manually maintained controlled vocabulary (RCV) for use in over-representation analysis. Many terms in this vocabulary group GO terms in novel ways that cannot

SUBMITTER: Osumi-Sutherland DJ 

PROVIDER: S-EPMC5813370 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature