Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density.

ABSTRACT:

Background

Mammographic breast density is one of the strongest risk factors for breast cancer, but molecular understanding of how breast density relates to cancer risk is less complete. Studies of proteins in blood plasma, possibly associated with mammographic density, are well-suited as these allow large-scale analyses and might shed light on the association between breast cancer and breast density.

Methods

Plasma samples from 1329 women in the Swedish KARMA project, without prior history of breast cancer, were profiled with antibody suspension bead array (SBA) assays. Two sample sets comprising 729 and 600 women were screened by two different SBAs targeting a total number of 357 proteins. Protein targets were selected through searching the literature, for either being rela

SUBMITTER: Bystrom S 

PROVIDER: S-EPMC5813412 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature