An observational study on risk of secondary cancers in chronic myeloid leukemia patients in the TKI era in the United States.

ABSTRACT:

Introduction

The treatment with tyrosine kinase inhibitors (TKIs) has drastically improved the outcome of chronic myeloid leukemia (CML) patients. This study was conducted to examine the risk of secondary cancers (SCs) in the CML patients who were diagnosed and treated in the TKI era in the United States.

Methods

The surveillance epidemiology and end results (SEER) database was used to identify CML patients who were diagnosed and received treatment during January 2002-December 2014. Standardized incidence ratios (SIRs) and absolute excess risks (AER) were calculated.

Results

Overall, 511 SCs (excluding acute leukemia) developed in 9,200 CML patients followed for 38,433 person-years. The risk of developing SCs in the CML patients was 30% higher than the age, sex and ra

SUBMITTER: Kumar V 

PROVIDER: S-EPMC5813591 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature