Metabolic Clusters and Outcomes in Older Adults: The Cardiovascular Health Study.

ABSTRACT: BACKGROUND/OBJECTIVES:Few studies have the requisite phenotypic information to define metabolic patterns that may inform our understanding of the pathophysiology and consequences of diabetes in older adults. We sought to characterize clusters of older adults on the basis of shared metabolic features. DESIGN:Population-based prospective cohort study. SETTING:Four U.S. Cardiovascular Health Study field centers. PARTICIPANTS:Individuals aged 65 and older taking no glucose-lowering agents (N = 2,231). MEASUREMENTS:K-means cluster analysis of 11 metabolic parameters (fasting and postload serum glucose and plasma insulin, fasting C-peptide, body mass index, C-reactive protein (CRP), estimated glomerular filtration rate (eGFR), albuminuria, carboxymethyl lysine (an advanced glycation end-product)

SUBMITTER: Mukamal KJ 

PROVIDER: S-EPMC5813705 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature