DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk.

ABSTRACT: Overall shared DNA methylation patterns between senescence (Sen) and cancers have led to the model that tumor-promoting epigenetic patterns arise through senescence. We show that transformation-associated methylation changes arise stochastically and independently of programmatic changes during senescence. Promoter hypermethylation events in transformation involve primarily pro-survival and developmental genes, similarly modified in primary tumors. Senescence-associated hypermethylation mainly involves metabolic regulators and appears early in proliferating "near-senescent" cells, which can be immortalized but are refractory to transformation. Importantly, a subset of transformation-associated hypermethylated developmental genes exhibits highest methylation gains at all age-associated cance

SUBMITTER: Xie W 

PROVIDER: S-EPMC5813821 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature