Mouse population-based evaluation of urinary protein and miRNA biomarker performance associated with cisplatin renal injury.

ABSTRACT: Discovery and qualification of novel biomarkers with improved specificity and sensitivity for detection of xenobiotic-induced injuries is an area of active research across multiple sectors. However, the majority of efforts in this arena have used genetically limited rodent stocks that lack variability in xenobiotic responses inherent to genetically heterogeneous human populations. In this study, genetically diverse Diversity Outbred (DO) mice were used as a surrogate for human clinical populations to investigate performance of urinary kidney biomarkers against classical preclinical kidney injury biomarkers (blood urea nitrogen [BUN] and serum creatinine). In this study, cisplatin was used as a paradigm kidney toxicant, with female adult DO mice exposed to a single injection (5 mg/kg) of ci

SUBMITTER: Harrill AH 

PROVIDER: S-EPMC5813868 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature