Short-term repeated HRV-16 exposure results in an attenuated immune response in vivo in humans.

ABSTRACT:

Introduction

Naturally, development of adaptive immunity following HRV infection affects the immune response. However, it is currently unclear whether or not HRV re-exposure within a short time frame leads to an altered innate immune response. The "experimental cold model" is used to investigate the pathogenesis of HRV infection and allows us to investigate the effects of repeated exposure on both local and systemic innate immunity.

Methods

40 healthy male and female (1:1) subjects were nasally inoculated with HRV-16 or placebo. One week later, all subjects received HRV-16. Baseline seronegative subjects (n = 18) were included for further analysis.

Results

Infection rate was 82%. Primary HRV infection induced a marked increase in viral load and IP-10 levels in nasal w

SUBMITTER: Koch RM 

PROVIDER: S-EPMC5813921 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature