Quantification of fetal organ volume and fat deposition following in utero exposure to maternal Western Diet using MRI.

ABSTRACT:

Purpose

To examine the feasibility of using MRI to identify differences in liver size and fat deposition in fetal guinea pigs exposed to an in utero environment influenced by maternal consumption of a Western diet.

Materials and methods

Female guinea pigs fed either an energy-dense Western Diet (WD), comprised of increased saturated fats and simple sugars, or a Control Diet (CD) from weaning through pregnancy, underwent MR scanning near term (~ 60 days; term ~ 69 days). Maternal weights were collected at mating and at MR scanning. T1-weighted, T2-weighted, and IDEAL water-fat images were acquired at 3 Tesla. The images were used to segment maternal adipose tissue, fetal liver, fetal brain, fetal adipose tissue, and total fetal volumes and to measure maternal and fetal hepati

SUBMITTER: Sinclair KJ 

PROVIDER: S-EPMC5814025 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature