Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue.

ABSTRACT: Although cellular therapies represent a promising strategy for a number of conditions, current approaches face major translational hurdles, including limited cell sources and the need for cumbersome pre-processing steps (for example, isolation, induced pluripotency). In vivo cell reprogramming has the potential to enable more-effective cell-based therapies by using readily available cell sources (for example, fibroblasts) and circumventing the need for ex vivo pre-processing. Existing reprogramming methodologies, however, are fraught with caveats, including a heavy reliance on viral transfection. Moreover, capsid size constraints and/or the stochastic nature of status quo approaches (viral and non-viral) pose additional limitations, thus highlighting the need for safer and more determinist

SUBMITTER: Gallego-Perez D 

PROVIDER: S-EPMC5814120 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature