Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis.

ABSTRACT: Semaphorin-5A (SEMA5A) has differential cell surface expression between normal and cancer cells and represents an attractive target for therapeutic intervention in pancreatic cancer (PC). In this study, we delineated the pathological expression and significance of SEMA5A during PC progression and metastasis. We utilized human tissue microarrays and different PC mouse models (Pdx1-cre; LSL- Kras^(G12D), Pdx1-Cre; LSL-Kras^(G12D); LSL-p53^(R172H) and RIP1-Tag2) to analyze SEMA5A expression during PC progression. Using human patients and different mouse models, we demonstrated that SEMA5A expression was highest in liver metastases, followed by primary pancreatic tumors, and the lowest expression was found in the normal pancreas. SEMA5A expression was localized on

SUBMITTER: Saxena S 

PROVIDER: S-EPMC5814185 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature