Effects of interactions between common genetic variants and alcohol consumption on colorectal cancer risk.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified approximately 40 common genetic loci associated with colorectal cancer risk. To investigate possible gene-environment interactions (GEIs) between GWAS-identified single-nucleotide polymorphisms (SNPs) and alcohol consumption with respect to colorectal cancer, a hospital-based case-control study was conducted.

Results

Higher levels of alcohol consumption as calculated based on a standardized definition of a drink (1 drink=12.5g of ethanol) were associated with increased risk of colorectal cancer (OR=2.47, 95% CI=1.62-3.76 for heavy drinkers [>50g/day] compared to never drinkers; p_trend<0.01). SNP rs6687758 near the DUSP10 gene at 1q41 had a statistically significant interaction with alc

SUBMITTER: Song N 

PROVIDER: S-EPMC5814220 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature