The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection.

ABSTRACT: Glioblastoma presents as a heterogeneous disease with poor prognosis despite the use of multimodal therapy. Analysis of genomic DNA changes between initial diagnosis and recurrence in response to standard treatment protocols would enhance understanding of disease progression and better inform new treatment strategies. A cohort of 21 patients with primary glioblastoma were examined between diagnosis and first recurrence. This study presented a rare opportunity to characterize molecular alterations in tumors observed in three patients who received no therapeutic intervention, other than surgery, offering a unique control. We focused this study by comparing the dynamic mutation profiles between the primary tumors and their matched recurrent counterparts. Molecular profiling of tumors was perf

SUBMITTER: Muscat AM 

PROVIDER: S-EPMC5814263 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature