Network analysis of microRNAs, genes and their regulation in diffuse and follicular B-cell lymphomas.

ABSTRACT: MicroRNAs (miRs) are short non-coding regulatory RNAs that control gene expression at the post-transcriptional level and play an important role in cancer development and progression, acting either as oncogenes or as tumor suppressors. Identification of aberrantly expressed miRs in patients with hematological malignancies as compared to healthy individuals has suggested that these molecules may serve as novel clinical diagnostic and prognostic biomarkers. We conducted a systematic literature review of articles published between 2007 and 2017 and re-analyzed experimentally-validated human miR expression signatures in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) from various biological sources (tumor tissue, peripheral blood, bone marrow and cell lines). A unique miR exp

SUBMITTER: Hershkovitz-Rokah O 

PROVIDER: S-EPMC5814270 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature