A metabolomic study on early detection of steroid-induced avascular necrosis of the femoral head.

ABSTRACT: The early and accurate diagnosis of steroid-induced avascular necrosis of the femoral head (SANFH) is appealing considering its irreversible progression and serious consequence for the patients. The purpose of this study was to investigate the metabolic change of SANFH for its early detection. Two stages were designed in this study, namely discovery and verification. Except the biochemical index anomaly and the accidental death, 30 adult healthy adult Japanese white rabbits were used for screening out the potential metabolites in discovery experiment and 13 rabbits were used in verification experiment. The femoral heads were assessed with magnetic resonance imaging and transmission electron microscopy. The metabolomic profiling of serum samples were analysis by UHPLC-MS/MS. Metabolomic clu

SUBMITTER: Ren X 

PROVIDER: S-EPMC5814275 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature