Prognostic role of tumor-infiltrating CD57-positive lymphocytes in solid tumors: a meta-analysis.

ABSTRACT: The prognostic role of tumor-infiltrating CD57-positive lymphocytes (CD57⁺ lymphocytes) in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 26 published studies with 7656 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating CD57⁺ lymphocytes in human solid tumors. We found that CD57⁺ lymphocyte infiltration significantly improved overall survival (OS) including 1 - year, 3 - year and 5 - year survival, and disease - free survival (DFS) in all types of solid tumors. In stratified analyses, CD57⁺ lymphocyte infiltration was significantly associated with better OS in hepatocellular, esophageal, head and neck carcinoma, non-small cell lung cancer, 5 - year survival in

SUBMITTER: Hu G 

PROVIDER: S-EPMC5814286 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature