Newly breeding an inbred strain of ischemia-prone Mongolian gerbils and its reproduction and genetic characteristics.

ABSTRACT: The Mongolian gerbil has been a useful laboratory animal in many research fields, especially in ischemia studies. However, due to the variation of the circle of Willis (COW), the ischemic model is unstable and various. To solve this problem, we newly established an inbred strain of gerbils, restricting breeding and keeping to F₂₃. The data on the breeding and growth of the animals are described in the present study. The genetic characteristics of F₄ to F₂₀ detected by microsatellite DNA and biochemical markers are also shown here. The results demonstrated that the frequency of ischemic model by unilateral carotid occlusion and the frequency of incomplete COW increased, increasing from 50% and 75% in F₁ to 88.89% and 100% in F₂₀, respec

SUBMITTER: Du X 

PROVIDER: S-EPMC5814317 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature