Newest Drugs for Chronic Unexplained Nausea and Vomiting.

ABSTRACT:

Opinion statement

Chronic unexplained nausea and vomiting (CUNV) refers to a symptom complex defined by nausea and/or vomiting with normal diagnostic testing, including anatomic assessments (including upper endoscopy) and measures of upper gut function (e.g., gastric emptying testing). Nausea and vomiting in this condition are postulated to result from aberrant peripheral or central neurohumoral activity. A substantial subset of patients satisfies this diagnosis as more than half of individuals referred for scintigraphic testing exhibit normal gastric emptying rates. No randomized, placebo-controlled trials of any medication treatment have been performed in CUNV. However, agents with potential therapeutic benefits in CUNV include antiemetic drugs, neuromodulatory treatments which a

SUBMITTER: Hasler WL 

PROVIDER: S-EPMC5814321 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature