Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients.

ABSTRACT: Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associated with overall survival in 632 patients with osteosarcoma, including 523 patients of European ancestry and 109 from Brazil. We conducted a time-to-event analysis and estimated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards models, with and without adjustment for metastatic disease. The results were combined across the European and Brazilian case sets using a random-effects meta-analysis. The strongest association after meta-analysis was for rs3765555 at 9p24.

SUBMITTER: Koster R 

PROVIDER: S-EPMC5814322 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature