C-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.

ABSTRACT: Both microbial and host genetic factors contribute to the pathogenesis of autoimmune diseases. There is accumulating evidence that microbial species that potentiate chronic inflammation, as in inflammatory bowel disease, often also colonize healthy individuals. These microorganisms, including the Helicobacter species, can induce pathogenic T cells and are collectively referred to as pathobionts. However, how such T cells are constrained in healthy individuals is not yet understood. Here we report that host tolerance to a potentially pathogenic bacterium, Helicobacter hepaticus, is mediated by the induction of RORγt⁺FOXP3⁺ regulatory T (iT_reg) cells that selectively restrain pro-inflammatory T helper 17 (T_H17) cells and whose function is dependent

SUBMITTER: Xu M 

PROVIDER: S-EPMC5814346 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature