Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle.

ABSTRACT: Because of the serious side effects of the currently used bronchodilators, new compounds with similar functions must be developed. We screened several herbs and found that Polygonum aviculare L. contains ingredients that inhibit the precontraction of mouse and human airway smooth muscle (ASM). High K⁺-induced precontraction in ASM was completely inhibited by nifedipine, a selective blocker of L-type voltage-dependent Ca²⁺ channels (LVDCCs). However, nifedipine only partially reduced the precontraction induced by acetylcholine chloride (ACH). Additionally, the ACH-induced precontraction was partly reduced by pyrazole-3 (Pyr3), a selective blocker of TRPC3 and stromal interaction molecule (STIM)/Orai channels. These channel-mediated currents were inhibited by the compou

SUBMITTER: Luo X 

PROVIDER: S-EPMC5814568 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature