Genomic basis of recombination suppression in the hybrid between Caenorhabditis briggsae and C. nigoni.

ABSTRACT: DNA recombination is required for effective segregation and diversification of genomes and for the successful completion of meiosis. Recent studies in various species hybrids have demonstrated a genetic link between DNA recombination and speciation. Consistent with this, we observed a striking suppression of recombination in the hybrids between two nematodes, the hermaphroditic Caenorhabditis briggsae and the gonochoristic C. nigoni. To unravel the molecular basis underlying the recombination suppression in their hybrids, we generated a C. nigoni genome with chromosome-level contiguity and produced an improved C. briggsae genome with resolved gaps up to 2.8 Mb. The genome alignment reveals not only high sequence divergences but also pervasive intra- and inter-chromosomal sequence re-arrang

SUBMITTER: Ren X 

PROVIDER: S-EPMC5814819 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature