Enantioselective Photochemical Organocascade Catalysis.

ABSTRACT: Reported herein is a photochemical cascade process that combines the excited-state and ground-state reactivity of chiral organocatalytic intermediates. This strategy directly converts racemic cyclopropanols and α,β-unsaturated aldehydes into stereochemically dense cyclopentanols with exquisite stereoselectivity. Mechanistic investigations have enabled elucidating the origin of the stereoconvergence, which is governed by a kinetic resolution process.

SUBMITTER: Wozniak L 

PROVIDER: S-EPMC5814823 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature