Photo-responsive Bioactive Surfaces Based on Cucurbit[8]uril-Mediated Host-Guest Interactions of Arylazopyrazoles.

ABSTRACT: A photoswitchable arylazopyrazole (AAP) derivative binds with cucurbit[8]uril (CB[8]) and methylviologen (MV²⁺ ) to form a 1:1:1 heteroternary host-guest complex with a binding constant of K_a =2×10³  m^-1 . The excellent photoswitching properties of AAP are preserved in the inclusion complex. Irradiation with light of a wavelength of 365 and 520 nm leads to quantitative E- to Z- isomerization and vice versa, respectively. Formation of the Z-isomer leads to dissociation of the complex as evidenced using ¹ H NMR spectroscopy. AAP derivatives are then used to immobilize bioactive molecules and photorelease them on demand. When Arg-Gly-Asp-AAP (AAP-RGD) peptides are attached to surface bound CB[8]/MV²⁺ complexes, cells adhere and

SUBMITTER: Wiemann M 

PROVIDER: S-EPMC5814888 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature