Copper 64-labeled daratumumab as a PET/CT imaging tracer for multiple myeloma.

ABSTRACT: As a growing number of patients with multiple myeloma (MM) respond to upfront therapies while eventually relapsing in a time frame that is often unpredictable, attention has increasingly focused on developing novel diagnostic criteria to also account for disease dissemination. Positron emission tomography/computed tomography (PET/CT) is often used as a noninvasive monitoring strategy to assess cancer cell dissemination, but because the uptake of the currently used radiotracer 18fluorodeoxyglucose (¹⁸F-FDG) is a function of the metabolic activity of both malignant and nonmalignant cells, the results frequently lack sufficient specificity. Radiolabeled antibodies targeting MM tissue may detect disease irrespective of cell metabolism. Hence, we conjugated the clinically significant

SUBMITTER: Caserta E 

PROVIDER: S-EPMC5814935 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature