Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study : A Randomized Clinical Trial.

ABSTRACT:

Importance

Cohort studies have reported increased incidence of cardiovascular disease (CVD) among individuals with low vitamin D status. To date, randomized clinical trials of vitamin D supplementation have not found an effect, possibly because of using too low a dose of vitamin D.

Objective

To examine whether monthly high-dose vitamin D supplementation prevents CVD in the general population.

Design, setting, and participants

The Vitamin D Assessment Study is a randomized, double-blind, placebo-controlled trial that recruited participants mostly from family practices in Auckland, New Zealand, from April 5, 2011, through November 6, 2012, with follow-up until July 2015. Participants were community-resident adults aged 50 to 84 years. Of 47 905 adults invited from famil

SUBMITTER: Scragg R 

PROVIDER: S-EPMC5815022 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature