Effect of Intravenous Ferric Carboxymaltose on Hemoglobin Response Among Patients With Acute Isovolemic Anemia Following Gastrectomy: The FAIRY Randomized Clinical Trial.

ABSTRACT:

Importance

Acute isovolemic anemia occurs when blood loss is replaced with fluid. It is often observed after surgery and negatively influences short-term and long-term outcomes.

Objective

To evaluate the efficacy and safety of ferric carboxymaltose to treat acute isovolemic anemia following gastrectomy.

Design, setting, and participants

The FAIRY trial was a patient-blinded, randomized, phase 3, placebo-controlled, 12-week study conducted between February 4, 2013, and December 15, 2015, in 7 centers across the Republic of Korea. Patients with a serum hemoglobin level of 7 g/dL to less than 10 g/dL at 5 to 7 days following radical gastrectomy were included.

Interventions

Patients were randomized to receive a 1-time or 2-time injection of 500 mg or 1000 mg of fer

SUBMITTER: Kim YW 

PROVIDER: S-EPMC5815040 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature