Association Between Skin and Aortic Vascular Inflammation in Patients With Psoriasis: A Case-Cohort Study Using Positron Emission Tomography/Computed Tomography.

ABSTRACT:

Importance

Inflammation is critical in the development of atherosclerosis. Psoriasis is a chronic inflammatory skin disease that is associated with increased vascular inflammation by 18fluorodeoxyglucose positron emission tomography/computed tomography in vivo and future cardiovascular events. It provides a human model to understand the effect of treating inflammation in a target organ (eg, the skin) on vascular diseases.

Objective

To investigate the association between change in skin disease severity and change in vascular inflammation at 1 year and to characterize the impact of 1 year of anti-tumor necrosis factor therapy on vascular inflammation.

Design, setting, and participants

In this prospective cohort study, 220 participants from outpatient practices were recr

SUBMITTER: Dey AK 

PROVIDER: S-EPMC5815046 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature