Histologic chorioamnionitis in preterm infants: correlation with brain magnetic resonance imaging at term equivalent age.

ABSTRACT:

Background

To explore the associations between histologic chorioamnionitis with brain injury, maturation and size on magnetic resonance imaging (MRI) of preterm infants at term equivalent age.

Methods

Preterm infants (23-36 weeks' gestational age) were recruited into two longitudinal cohort studies. Presence or absence of chorioamnionitis was obtained from placental histology and clinical data were recorded. MRI at term-equivalent age was assessed for brain injury (intraventricular haemorrhage, cysts, signal abnormalities), maturation (degree of myelination, gyral maturation) and size of cerebral structures (metrics and brain segmentation). Histologic chorioamnionitis was assessed as a predictor of MRI variables using linear and logistic regression, with adjustment for confo

SUBMITTER: Granger C 

PROVIDER: S-EPMC5815189 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature