Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.

ABSTRACT:

Background

Mammalian species exhibit a wide range of lifespans. To date, a robust and dynamic molecular readout of these lifespan differences has not yet been identified. Recent studies have established the existence of ageing-associated differentially methylated positions (aDMPs) in human and mouse. These are CpG sites at which DNA methylation dynamics show significant correlations with age. We hypothesise that aDMPs are pan-mammalian and are a dynamic molecular readout of lifespan variation among different mammalian species.

Results

A large-scale integrated analysis of aDMPs in six different mammals reveals a strong negative relationship between rate of change of methylation levels at aDMPs and lifespan. This relationship also holds when comparing two different dog breeds

SUBMITTER: Lowe R 

PROVIDER: S-EPMC5815211 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature