Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria.

ABSTRACT:

Background

Chitinase-3-like 1 (CHI3L1) is a glycoprotein elevated in paediatric severe malaria, and an emerging urinary biomarker of acute kidney injury (AKI). Based on the hypothesis that elevated CHI3L1 levels in malaria are associated with disease severity, the relationship between plasma CHI3L1 levels, AKI and mortality was investigated in Ugandan children enrolled in a clinical trial evaluating inhaled nitric oxide (iNO) as an adjunctive therapy for severe malaria.

Methods

Plasma CHI3L1 levels were measured daily for 4 days in children admitted to hospital with severe malaria and at day 14 follow up. AKI was defined using the Kidney Disease: Improving Global Outcomes consensus criteria. This is a secondary analysis of a randomized double-blind placebo-controlled trial o

SUBMITTER: Conroy AL 

PROVIDER: S-EPMC5815237 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature