Robust symptom networks in recurrent major depression across different levels of genetic and environmental risk.

ABSTRACT:

Background

Genetic risk and environmental adversity-both important risk factors for major depression (MD)-are thought to differentially impact on depressive symptom types and associations. Does heterogeneity in these risk factors result in different depressive symptom networks in patients with MD?

Methods

A clinical sample of 5784 Han Chinese women with recurrent MD were interviewed about their depressive symptoms during their lifetime worst episode of MD. The cases were classified into subgroups based on their genetic risk for MD (family history, polygenic risk score, early age at onset) and severe adversity (childhood sexual abuse, stressful life events). Differences in MD symptom network structure were statistically examined for these subgroups using permutation-based net

SUBMITTER: van Loo HM 

PROVIDER: S-EPMC5815316 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature