Biomarkers of Cerebral Injury and Inflammation in Pediatric Tuberculous Meningitis.

ABSTRACT:

Background

Tuberculous meningitis (TBM) leads to death or disability in half the affected individuals. Tools to assess severity and predict outcome are lacking. Neurospecific biomarkers could serve as markers of the severity and evolution of brain injury, but have not been widely explored in TBM. We examined biomarkers of neurological injury (neuromarkers) and inflammation in pediatric TBM and their association with outcome.

Methods

Blood and cerebrospinal fluid (CSF) of children with TBM and hydrocephalus taken on admission and over 3 weeks were analyzed for the neuromarkers S100B, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP), in addition to multiple inflammatory markers. Results were compared with 2 control groups: patients with (1) a fatty fil

SUBMITTER: Rohlwink UK 

PROVIDER: S-EPMC5815568 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature