Comparative genomic analysis of the multispecies probiotic-marketed product VSL#3.

ABSTRACT: Several probiotic-marketed formulations available for the consumers contain live lactic acid bacteria and/or bifidobacteria. The multispecies product commercialized as VSL#3 has been used for treating various gastro-intestinal disorders. However, like many other products, the bacterial strains present in VSL#3 have only been characterized to a limited extent and their efficacy as well as their predicted mode of action remain unclear, preventing further applications or comparative studies. In this work, the genomes of all eight bacterial strains present in VSL#3 were sequenced and characterized, to advance insights into the possible mode of action of this product and also to serve as a basis for future work and trials. Phylogenetic and genomic data analysis allowed us to identify the 7 spec

SUBMITTER: Douillard FP 

PROVIDER: S-EPMC5815585 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature