Coactivation of Estrogen Receptor and IKKβ Induces a Dormant Metastatic Phenotype in ER-Positive Breast Cancer.

ABSTRACT: A growing body of evidence suggests that the inflammatory NFκB pathway is associated with the progression of ER⁺ tumors to more aggressive stages. However, it is unknown whether NFκB is a driver or a consequence of aggressive ER⁺ disease. To investigate this question, we developed breast cancer cell lines expressing an inducible, constitutively active form of IκB kinase β (CA-IKKβ), a key kinase in the canonical NFκB pathway. We found that CA-IKKβ blocked E2-dependent cell proliferation in vitro and tumor growth in vivo in a reversible manner, suggesting that IKKβ may contribute to tumor dormancy and recurrence of ER⁺ disease. Moreover, coactivation of ER and IKKβ promoted cell migration and invasion in vitro and drove experimental meta

SUBMITTER: El-Shennawy L 

PROVIDER: S-EPMC5815896 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature