Preliminary mapping of the structural effects of age in pediatric bipolar disorder with multimodal MR imaging.

ABSTRACT: This study investigates multimodal structural MR imaging biomarkers of development trajectories in pediatric bipolar disorder. T1-weighted and diffusion-weighted MR imaging was conducted to investigate cross-sectional group differences with age between typically developing controls (N = 26) and youths diagnosed with bipolar disorder (N = 26). Region-based analysis was used to examine cortical thickness of gray matter and diffusion tensor parameters in superficial white matter, and tractography-based analysis was used to examine deep white matter fiber bundles. Patients and controls showed significantly different maturation trajectories across brain areas; however, the magnitude of differences varied by region. The rate of cortical thinning with age was greater in patients than controls in

SUBMITTER: Cabeen RP 

PROVIDER: S-EPMC5815932 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature