Defining SNAP by cross-sectional and longitudinal definitions of neurodegeneration.

ABSTRACT:

Introduction

Suspected non-Alzheimer's pathophysiology (SNAP) is a biomarker driven designation that represents a heterogeneous group in terms of etiology and prognosis. SNAP has only been identified by cross-sectional neurodegeneration measures, whereas longitudinal measures might better reflect "active" neurodegeneration and might be more tightly linked to prognosis. We compare neurodegeneration defined by cross-sectional 'hippocampal volume' only (SNAP/L-) versus both cross-sectional and longitudinal 'hippocampal atrophy rate' (SNAP/L+) and investigate how these definitions impact prevalence and the clinical and biomarker profile of SNAP in Mild Cognitive Impairment (MCI).

Methods

276 MCI patients from ADNI-GO/2 were designated amyloid "positive" (A+) or "negative" (A-) b

SUBMITTER: Wisse LEM 

PROVIDER: S-EPMC5816023 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature