Respiratory Disease following Viral Lung Infection Alters the Murine Gut Microbiota.

ABSTRACT: Alterations in the composition of the gut microbiota have profound effects on human health. Consequently, there is great interest in identifying, characterizing, and understanding factors that initiate these changes. Despite their high prevalence, studies have only recently begun to investigate how viral lung infections have an impact on the gut microbiota. There is also considerable interest in whether the gut microbiota could be manipulated during vaccination to improve efficacy. In this highly controlled study, we aimed to establish the effect of viral lung infection on gut microbiota composition and the gut environment using mouse models of common respiratory pathogens respiratory syncytial virus (RSV) and influenza virus. This was then compared to the effect of live attenuated influen

SUBMITTER: Groves HT 

PROVIDER: S-EPMC5816042 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature